Serum-ascites albumin gradient (SAAG) is more useful than the total protein concentration of ascitic fluid in the classification of ascites. This gradient is physiologically based on oncotic-hydrostatic balance and is related directly to portal pressure.
Then, what does SAAG score mean?
The SAAG is a physiological clinical diagnostic tool for the evaluation of ascites. An increased SAAG (> 1.1 gm/dL) value indicates the presence of portal hypertension, which is detected by observing portal hypertensive changes in the upper gastrointestinal tract.
Important causes of high SAAG ascites (> 1.1 g/dL, >11 g/L) include: cirrhosis of the liver, heart failure, Budd-Chiari syndrome, portal vein thrombosis, and idiopathic portal fibrosis.>>>
Similarly, how is SAAG calculated?
SAAG is the standard for defining presence of portal hypertension (does not differentiate cause) in patients with ascites. Formula : SAAG = (albumin concentration of serum) – (albumin concentration of ascitic fluid).
What does low SAAG mean?
A low gradient (SAAG < 1.1 g/dL) indicates nonportal hypertension and suggests a peritoneal cause of ascites. Such conditions may include the following: Primary peritoneal mesothelioma. Secondary peritoneal carcinomatosis.
How do you interpret a SAAG ratio?
A high SAAG (>1.1g/dL) suggests the ascitic fluid is a transudate
- Malignancy.
- Infection.
- Pancreatitis.
- Nephrotic syndrome.
What is low SAAG ascites?
Low SAAG ascites (<1.1 g/dL) is usually caused by peritoneal malignancies, chronic peritoneal infection (i.e., mycobacterium tuberculosis), and nephrotic syndrome. Cancers that spread to the omentum and result in ascites are typically of ovarian, gastric, or pancreatic origin.