An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity.
Moreover, what is a Raf inhibitor?
RAF inhibitor binds preferentially to BRAF and inactivates it, but also causes transactivation of the associated CRAF, enhancing MEK-ERK activation and cellular proliferation. That chemotherapy can both cure and cause cancer is not a new concept.